Manufaqctured by: Pfizer
What is the dosage form and potwncy of RELPax?
You can find it as 20mg and 40mg strength tablets.
What is Relpax? You use Relpax for treating migraine attacks or migraine headache. Migraine is a severely disturbing single sided headache that can cause nausea, vomiting and tiredness and may or may not worsen with the exposure to light, noise, and various odors etc. This kind of headache can take place at any time can hinder a person from daily work routine. Relpax can be used by both genders.
What should you know about Relpax?
There are some important points you should always keep in mind while taking this drug;
- It is a very good practice to always read the medication guide.
- You should avoid using this drug for the sole purposes of preventing the headaches.
- Relpax is specifically to be used for migraine. Never use this medicine for any other type of headaches.
- If you feel no difference in your headache after taking the first tablet, avoid taking another dose and consult your physician as you might require further diagnosis or changes in your regimen.
- If your headache subsides after taking the first dose but recurs then you can take another tablet after the gap of 2 hours from the first dose.
- Do not drive or operate heavy machinery after taking Relpax.
- You need to promptly consult your doctor on developing signs of pain, tightness, pressure in your throat, neck, jaws, or chest because this drug is well known for its vessel spasm producing properties.
- Do not administer Relpax if you have any other nervous system related disorder.
- You must immediately stop treatment with Relpax and contact the emergency numbers if you get an allergic reaction to the drug. The symptoms could range from minor coughing, rash to serious wheezing, swelling and tightened airways which would lead to difficulty in breathing.
- You should never treat your migraines with Relpax if you had a stroke in the past, or are paralyzed as it could double your risk for having another stroke.
- This drug can raise the blood pressure in your body, so don’t take Relpax if you suffer from uncontrollable high blood pressure.
- This medicine is not to be used if you have a major depression, anxiety or any other related condition and you are getting treatment for it due to the reason of serious interaction of Relpax with the medicines used for treating such conditions.
- Defer from using this drug if you have an inflammatory problem in your digestive system.
- Never under any condition ingest the tablets of Relpax with any other ergotamine containing compounds such as methylergonovine (Methergine), dihydroergotamine (D.H.E. 45, Migranal), methysergide (Sansert), caffeine and ergotamine (Cafergot0.
- This drug is not for you if you have angina (chest pains on exertion), history of a heart attack, a condition that involves irregular beating of the heart called arrhythmias.
- This medicine does not cause fat deposition in the body.
- Consult your pharmacist to learn which drugs can be taken and which are to be avoided with Relpax.
How to use this medicine?
You should always;
- Take the doses according to your doctor’s recommendations. Taking it in higher doses can cause or worsen the already existing headaches.
- Bring one tablet with a glass of water when you begin detecting the indications of the cerebral pains. If your headaches don’t improve after taking the first tablet or you accidently take more than prescribed, talk to your doctor.
- Swallow the whole tablet.
- It can be taken with or without sustenance. If your migraine is accompanied with nausea and vomiting, take the tablet on an empty stomach.
- Place the tablets at room temperature away from direct sunlight.
Does Relpax interact with other medicines?
If given with other compounds that contain ergot can cause additive effects of vasospasm and constriction of the blood vessels that leads to elevated blood pressures. If given with medicines that are used for psychiatry purposes e.g. tricyclic anti-depressants or atypical anti depression medicines can cause a phenomenon called Serotonin Syndrome (which results in tremors, convulsions, high grade fever, diarrhea, fastened heartbeat, confusion etc.) due to the increased amount of serotonin in the body. The medicinal agents which increase the levels of Relpax should not be used in tandem. Such drugs include clarithromycin, glucocorticoids, diltiazem, anastrozole, disulfiram, isoniazid, erythromycin etc.
Side effects produced by Relpax:
Apart from the desired effects, you can also experience the following side effects produced by this drug;
Redness, headache, heart burn and indigestion, tightened muscles, dizziness, weakness, pain, shivering, sleepiness, palpitations, dried oral cavities, nausea, numbness in the fingers and toes, convulsions, heart attack.
In which cases Relpax should be avoided?
This drug is highly prohibited in the following conditions;
- Allergy to ergot and ergot like compounds
- Past history of stroke either ischemic or hemorrhagic
- Psychiatric and nervous system disorders and medicines for their treatment
- High blood pressure which is not responding to general anti-hypertensive medications
- Abnormal heart and vasculature state
- Inflamed digestive tract
- With other agents constituting ergot
- With certain medicines that inhibit the functioning of cytochrome iso-enzymes n the body. [see drug interactions]
How can this medication work?
A person experiences migraine due to the nearby cranial vasodilation and the arrival of tangible neuropeptides. Eletriptan helps in these conditions by binding to the serotonin receptors and constricting the widened blood vessels in the brain and also represses the release of inflammatory substances.
What does the body do to the drug (pharmacokinetics)?
Absorption: following the primary tablet almost 50% of the active drug becomes available in the body for its desired action with the peak response seen at 1.5-2 hours.
Distribution: about 138L of the drug gets distributed throughout the body out of which 85% binds to the blood proteins.
Metabolism an excretion: the metabolic processes of this drug take place in the liver and the metabolites get excreted via bile and feces.
Utilization of this medication in particular populaces:
- In pregnancy: it has a place with the classification C of drugs. It is only utilized if the benefits overweigh the dangers because there are no human trials available and in animal studies it has appeared that Eletriptan can harm the fetus during its developmental stages and can cause deformities in the body structure.
- In nursing mothers: Relpax does get discharged in the human milk so it should not be used by mothers while they are breast-feeding.
- In elderly patients: it is okay to be used by people above 60 years. Because older patients are more prone to the high blood pressure, it is necessary they monitor their blood pressure regularly.
- In younger patients: this drug can produce detrimental effects in children, therefore, avoid use.
- Gender differences: it can be used by men and women both.
- Ethnic differences: patients of Japanese descendants have lower levels of this drug than Western people. The exposure is same for Caucasians and non-Caucasians.
- Kidney and liver problems: you should not take Relpax if you have severe kidney and liver impairment.
Amid animal testing of Relpax it produced testicular cancer in male rats and in female rats it caused cancer of liver cells but it did not show any adverse effects on the genetic levels. It influenced just the female regenerative capacities.
What should you tell your specialist about?
Inform your doctor if you have;
- High blood pressure
- pregnant or breast-feeding a child
- Have any sort of depressive conditions
- Kidney or liver related problems
- Smoking problems
- Your menstrual stop
Which ingredients are present in this medicine?
It contains eletriptan hydrobromideas a major ingredient and contains microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, titanium dioxide, hypromellose, triacetin, and FD&C Yellow No. 6 aluminum lake as supplementary ingredients.