Patient Information on Nasonex (Mometasone furoate monohydrate)

 Manufactured by: Merck & Co., Inc.

What is Nasonex utilized for?

Nasonex is used for treating seasonal allergies and flu-like conditions. It is given to following patients;

  • Those who require occasional prophylaxis against unfavorably susceptible rhinitis, which includes the bodily fluid film of nose getting kindled.
  • For treating blockage of the nasal passages which could be the consequence of inflamed and swollen blood vessels of the nose.
  • Those who have developed nasal polyps; growth of small sized benign growths in the inside lining of the nose. These growths do not have cancerous properties.

What is the dosage form and potency (strength) of Nasonex?

You can find Nasonex in the type of a nasal spread holding 50 mcg from claiming mometasone furoate for each 100 microliter spread.

 What should you know about Nasonex?

  • Completely read the prescription aide before taking any pharmaceutical.
  • Before you use it make suure to shake it well.
  • You should discontinue Nasonex on experiencing any kind of allergic reactions e.g. redness, swollen lips, tongue, mouth, wheezing, shortness of breath, rash.
  • Try not to utilize Nasonex on the off chance that you had a nasal surgery, nasal injury or nasal septum ulcers (until mended).Avoid using this drug if you suffer from nose bleeds.
  • While you are using Nasonex, your doctor may need to examine you to make sure the medicine is not harming your nose or sinuses.
  • If you develop any sort of infection in the throat, stop taking Nasonex and get your doctor’s advice.
  • If you are taking Nasonex for more than a week, it is important that you visit your ophthalmologist periodically to make sure you are not developing cataracts.
  • Donot take this drug if you have life-threatening diseases, for example, tuberculosis, viral contaminations.
  • Do not provide this drug to children who are in their growing age.

 How do you take the drug?

  • You should only take the amount told by your doctor. Refrain from taking it in large amounts.
  • Only take Nasonex through nose and not from the mouth.
  • Before using it the first time, shake the bottle and spray two or three mists in the air.
  • Store it at 25°C (77°F).

To use the Nasonex nasal spray:

  • Tilt your head backwards and place the bottle’s nozzle in your nostril while shutting the other nostril with the assistance of your fingers.
  • Gently spray and do not blow your nose for 5-10 minutes to prevent wastage of the drug.

Contra-indications and precautions:

Do not administer this drug if you;

  • Are allergic to the whole drug or any other ingredient present in it.
  • Have nose bleeds, nasal surgery, injured nasal cavity, and ulcerated nasal membranes.
  • Have developed eye related conditions
  • Are currently suffering from pathogenic infections.
  • In children

How does it adversely affect you?

You may experience any of the given effects;

  • respiratory: infectious throat, cough, shortness of breath, flu-like syndrome.
  • eyes and ear: redness in the eyes, infections of the middle ear.
  • muscles: pain in the muscles
  • gastrointestinal system: diarrhea and vomiting.
  • Nose: nose bleeds, nasal fungal infections, burning and irritation of nose.
  • Others: viral infection, painful menstruation, suppressed growth
  • Post-Marketing Experience: nasal burning and irritation, hypersensitive reaction, disturbances in taste and smell.

How can Nasonex interact with the other drugs?

Drug interactions with Nasonex are yet to be conducted. However, CYP3A4 inhibitors (ketoconazole) may affect the metabolism of Nasonex.

Can this drug be used in the specific populations?

  • In pregnancy: this drug belongs to the category It should only be used in pregnant women when truly needed in the absence of other safer alternatives.
  • In Nursing Mothers: corticosteroids get secreted in human milk; therefore, Nasonex should not be used by such women.
  • In pediatrics: you should not give your child Nasonex for sole preventive purposes from flu.
  • In geriatrics: Nasonex can be safely used by elderly.

What is the mode of action of Nasonex?

It is an anti-inflammatory drug i.e. suppresses the immune system of the body. It rectifies the symptoms of rhinitis by depressing various inflammation causing cells, like mast cells and histamine.

What is the pharmacokinetics of this drug? Pharmacokinetics involve all those processes that a drug undergoes after its administration.

Absorption: only small ampunt of this drug gets swallowed

Distribution: about 98% to 99% of this drug binds to the plasma proteins.

Metabolism and Elimination: it gets metabolized by CYP3A4 enzymes of cytochrome system. Mometasone has a half-life of about 5.8 hours and any absorbed portion of the drug gets excreted via the bile.

How do different patient populations affect the Pharmacokinetics of this drug?

  • Levels and effects of Nasonex can increase in hepatic impairment.
  • gender, race, age, and renal impairment effects on this drug are still to be studied.

 What is the toxicology profile of this drug?

  • When it was subjected to non-human testing, Nasonex did not produce tumors or mutations in them.
  • It didn’t create any reproductive insufficiencies in rats subjected to testing of this medication. Nasonex produced difficulties in labor and caused a reduction in the birth weight of the animals treated with this drug.

What should you inform your doctor before using Nasonex?

Before taking Nasonex, a patient should inform his/her doctor about;

  • Infections if any
  • Cataracts
  • Tuberculosis infection
  • If had a nasal surgery, trauma or sores.

 

 

 

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