Patient Information on Myrbetriq (mirabegron)

Manufactured by: Astellas Pharma Inc.

When is Myrbetriq used? You will need to use Myrbetriq if you develop urinary incontinence due to an enlarged or over functioning bladder which leads to frequent bathroom visits and sometimes leakage of the urine on coughing, sneezing or laughing. It can be used by all genders.

How is it supplied? It is an orally taken dosage form as 25mg and 50 mg tablets. You can easily differentiate the two forms by looking at their colors. 25mg is of brown color whereas 50mg tablet is in the yellow coloring.

What is the drug’s dosing information? Never take Myrbetriq if you are in the end stage renal disease or have a severe liver failure.

How should the tablets be taken? You can ingest these tablets either on an empty stomach or within or after the meal (as suitable). Always swallow the tablet as a whole with a glass of water without chewing or breaking it. Make sure to stick to the regimen for full time as counseled by the doctor as this drug can take up to eight weeks to fully show its anticipated actions. Keep the tablets at the room temperature.

Which things should you be cautioned of about Myrbetriq?

While using this drug you should readily consult a pharmacist or a physician if you develop skin associated reactions (swollen lips, throat, face or tongue), any breathing difficulties, an uncontrollable rise in blood pressure, or inability to pass the urine. You should regularly measure your blood pressure to ensure no ascent in it due to this medicine.

What types of side effects Myrbetriq has? It can have the following noxious and disturbing adverse actions and you may experience one or more than one of these side effects.

High blood pressure, urethral infections, constipation, pain in the muscles particularly back muscles, flu, lightheadedness, bladder inflammation, stomachache, loose watery stools, throat inflammation and infections, rapid heartbeats, tiredness, increased ocular pressure, abnormal liver enzymes functioning, stone formation in the kidneys, skin rash, hives, vaginal infections, angioedema, headache, sinus blockage, heart burn, purple coloring of the skin, and abnormal cell growth.

What kind of medications does it interact with? It can safely be given with rifampicin (anti-TB), tamsulosin (for prostate enlargement), and ketoconazole (anti-fungal), oral contraceptives (birth control pills), solifenacin (incontinence).

The drugs with which it requires alterations include digoxin (start at lowest dosage of digoxin), metoprolol and desipramine (use alternative or closely monitor owing to the fact that mirabegron is a CYP2D6 enzyme inhibitor and these two drugs undergo metabolism via this specific class of isoenzymes), warfarin (may increase the levels of it, thus requires monitoring).

What precautionary measures should be taken with Myrbetriq?

Firstly, you should absolutely never take Myrbetriq in the cases of allergies to one of its components, if your blood pressure is not under control, if have any sort of a blockade in the bladder, if you are using anti-muscarinic drugs (atropine, scopolamine etc.) to prevent failure of urine expulsion and with any other such drugs with which Myrbetriq can interact.

What is the toxicological report of Myrbetriq? Mirabegron has not proven to be carcinogenic or mutagenic at non-lethal doses in the rats and has not affected their reproduction either.

Pups born to the mothers who were given Myrbetriq had enlarged heart and bone deformities. And the baby rats and mice who were subjected to breast milk of such mothers had mirabegron accumulated in their kidneys, lungs, and liver.

What is the pharmacodynamics of this drug?

Pharmacodynamics involves the processes that take place during the drug’s activities. Mirabegron attaches to the beta-3 adrenergic receptors residing in the bladder and on activation, these receptors relaxes the smooth muscles of the bladder and expands its urine holding capacity.

What is the pharmacokinetics of Myrbetriq? Pharmacokinetics involves the processes that undergo after the drug has shown its actions. Mirabegron, about 29-35% gets available in the body, with highest concentrations available after 4 hours. It has 1670L Vd (volume for distribution in the tissues) and undergoes hepatic metabolism. It is a moderate inhibitor of 2D6 isoenzymes of cytochrome enzymatic systems. Has a half-life of 50 hours (stays in the body for a longer time) and gets removed by feces (34%) and urine (55%) from the body.

Can Myrbetriq be used in different patients?

It belongs to C category and should only be used by pregnant or lactating women if truly required in the absence of any other options. Its use is safe for elderly people but is marked harmful for kids. Japanese people have more levels of Myrbetriq in their blood as compared to Americans. In terms of body weight, females have more exposure than their male partners.

What should you inform your doctor about? Before taking Myrbetriq tell your doctor if you have any eye, kidney, liver, heart, bladder diseases. If your blood pressure ranges to 180/120.  If pregnant or feeding.

Which compounds are used in the tablets? It has mirabegron, yellow ferric oxide, and red ferric oxide, polyethylene glycol, hydroxypropyl cellulose, magnesium stearate, hypromellose, butylated hydroxytoluene, polyethylene oxide.











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