Patient Information on Diovan (Valsartan)

Manufacturing company:  Novartis Pharmaceuticals Corp.

Why should you use Diovan?

It is utilized for the decrease of hypertension, heart-related occasions like heart attack and stroke. It is effective in both men and women. It can be taken as a solitary treatment or alongside other antihypertensive.

Complete effective treatment of the above conditions not only involves the management of elevated blood pressure but also includes proper control of diabetes, cholesterol, smoking, alcoholism, and exercise and sodium intake.

It is essential to treat hypertension since it can generally prompt various organ-related harms.

What is the potency of Diovan?

It is a 40mg, 80mg, 160mg and 320mg tablets.

What should be the dosing? Follow the dosing regimen prescribed by your specialist.

What should you know about Diovan?

  • You should have your blood pressure monitored regularly and it is great if you can keep a record if conceivable.
  • This medicine alone will not benefit you if you are of the dark race.
  • Take it after food.
  • Do not give it to children.
  • This medicine has proven to be beneficial in reducing heart failure events.
  • Never use this drug if you are bearing a child and terminate its use after talking to your doctor if you become pregnant during the use.
  • If your blood pressure levels do not return to normal after taking Diovan, do not self-medicate or increase the dose without consulting your doctor.
  • If you are diabetic and using a medicine Tekturna (Aliskiren), do not co-administer Diovan with it due to the high risks of acute failure and damage to the kidneys.
  • Get medical help if you develop rash on your skin.
  • Diovan is used with extreme care when the liver is compromised.
  • If you lose too much of your body fluid or blood through hemorrhage, vomiting, kidney failure, third-degree burns inform your respective doctor as it may require changes in your regimen.
  • If on the use of Diovan either alone or with other blood lowering agents, you start experiencing hypotensive symptoms such as fainting, lightheadedness, nausea, extreme tiredness, rapid deep breaths, and headache firstly intake something salty and follow-up on your doctor for any changes if required.
  • You may need your kidney tests directed after some season of beginning Diovan treatment as it can demonstrate harmful to the kidneys in elderly patients with advancing kidney capacity decrease and heart problems.
  • Do not take potassium supplements (until recommended) with Diovan as it could lead to extensively high levels of potassium in the body.

Can Diovan be used in different situations?

  • Pregnancy: it is a category D drug which means it has proven evidence of fetal harm in humans. A woman should be put off immediately after the confirmation of pregnancy. DO NOT USE IN PREGNANCY.
  • Lactation: valsartan was found present in rats’ milk during animal tests; no such tests are done in humans. Diovan should not be used by breast-feeders until truly medically essential.
  • Pediatrics: it is not for children’s use.
  • Geriatrics: it is considered safe.

What side-effects can Diovan produce?

System specific side effects are listed below;

  • Muscles: muscle cramps, pain in the back, tenderness in the muscles.
  • Ear: severe dizziness.
  • Gastric: gas accumulation, dry mouth, dyspepsia, and constipation, pain.
  • Lungs: labored breathing
  • Urogenital: sterility
  • Skin: rash, irritation, baldness.
  • Heart and vessels: Palpitations, low blood pressure, inflamed blood vessels.
  • Lab results: elevated blood urea, a decline in neutrophils, deranged liver enzymes, increased potassium levels.

Is this drug toxic?

Diovan did not demonstrate any harmful or mutagenic impacts in animals on which the medication was tried.

What are its contents? Diovan consists of valsartan, titanium dioxide, gelatin, cellulose compounds, crospovidone, iron oxides, sodium lauryl sulfate, povidone, magnesium stearate.

When is Diovan contra-indicated?

BLACK BOX WARNING: it should not be used by pregnant mothers.

CONTRA-INDICATIONS:

  • if allergic to the Angiotensin-receptor blocker class.
  • If using a renin inhibitor Aliskiren.

PRECAUTIONS: required in

  • liver diseases
  • kidney failure
  • heart failure
  • With other anti-hypertensive
  • body fluid loss
  • renal obstruction
  • hyperkalemia
  • Myocardial infarction
  • Surgery
  • With anesthetics

How does Diovan behave pharmacologically (mode of action)?

It lowers blood pressure by preventing blood vessel constriction and aldosterone (component involved in playing one of the major roles in hypertension) secretion by blocking angiotensin receptors.

What is the pharmacokinetics of Diovan?

  • Absorption and distribution: its actions start within 2 hours of ingestion of the tablets and continue until 24 hours. More than 90% of the drug binds to our blood proteins.
  • Metabolism and elimination: it is subjected to the liver for metabolism and to feces for its maximum removal.

Does Diovan have drug-interactions?

  • It neither alters nor gets altered by cimetidine, atenolol, hydrochlorothiazide, glyburide, furosemide, amlodipine, digoxin, warfarin, and indomethacin.
  • Its use should be avoided with pain-relieving medications known as NSAIDs in elderly patients as it could hasten renal dysfunction.
  • Valsartan with other antihypertensive medicines can cause hypotensive conditions.
  • Diovan with potassium-containing nutriceuticals, potassium expanding diuretics builds potassium levels to clinical huge levels.
  • Drugs like ritonavir, cyclosporine, and rifampicin which modulate OATP1B1 type of transporters in our body can cause fluctuations in Valsartan’s levels when used together.

Before taking Valsartan talk to your doctor if you have any conditions listed below;

  • Heart failure
  • Renal impairment
  • Liver impairment
  • Pregnancy or planning to become pregnant
  • Breast-feeding
  • Other medications
  • Allergies (food or medicine)
  • If you are on a sodium-restricted diet.
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