Patient Information on Celebrex (Celecoxib)

 

What is Celebrex used for?

It is a non-steroidal anti-inflammatory drug used for the relief of pain in the following scenarios;

  • Acute onset of pain
  • Familial adenomatous polyposis (FAP) which involves the formation of several polyps in intestines and colon.
  • In painful menstruation
  • Rheumatoid arthritis (inflammation of the joints)
  • Ankylosing Spondylitis (arthritis involving the spinal cord)
  • Juvenile Rheumatoid Arthritis JRA (occurs in children)
  • Osteoarthritis (degeneration of the joints and bones)

In which form is Celebrex available on the market?

It is a capsule formulation having potencies of 50mg, 100mg, 200mg and 400mg.

What is the dosing of this drug?

You should use Celebrex according to the recommendations of your doctor. The dosing of this medicine is done by keeping in perspective distinctive variables of an individual patient.

What should you know about Celebrex contra-indicatory and precautionary use?

BLACK BOX WARNINGS: Celecoxib can cause bleeding in the gastric tract and can lead to negative cardiac events.

  • It is better if you take it after a meal or a snack.
  • Do report an unexpected gain in weight to your doctor.
  • Immediately consult your doctor on developing any one or more of the below-given conditions;

Breathing problems, rash, itchy and irritated skin, stomachache, burning sensations in the stomach, upper gastric pain, yellowing of the skin, dark colored urine, high blood pressure, bleeding, accumulation of fluid in the appendages, chest pain.

  • Do not use any other NSAIDs (over the counter) with Celebrex as it can double the risks of acquiring adverse effects. Talk to your pharmacist about which medicines are to be avoided during Celebrex use.
  • Do not use this drug if you are allergic to other NSAIDs, aspirin or sulfonamide group of medicines.
  • You should avoid Celebrex if you have to undergo bypass.
  • This drug can increase your blood pressure, always report your doctor if your blood pressure remains rose and stops responding to your anti-hypertensive.
  • Celebrex will inhibit the blood pressure lowering effects of diuretics, angiotensin receptor blockers, and ACE inhibitors. If the use of Celebrex is necessary with these drugs; make sure to have your blood pressure observed frequently.
  • Your doctor may ask you to have your liver enzyme levels checked during your treatment with Celebrex due to the reason that it can elevate the liver enzymes, cause damage to the liver and liver cells.
  • This medication whenever amid its utilization can bring about serious digestive tract related issues such as ulceration, bleeding whose rate increases with progressing age, already existing hyperactive conditions in the stomach, with the use of alcohol, glucocorticoids.
  • It can cause clotting in the blood vessels, precipitate heart attack, and stroke.
  • When to be used for a prolonged time or in old age, you may need to have some kidney functioning tests to ensure that your kidneys have not been affected by this drug. It can by inhibit the production of renal prostaglandins can cause damage to the kidneys.
  • Do not give Celebrex to children.
  • If on treatment with Celebrex you get pregnant, immediately consult your doctor.

How does Celebrex interact with other drugs?

  • CYP2C9 inhibitors: it is metabolized through this very enzyme, so the agents (e.g. fluconazole, omeprazole) inhibiting it will alter the levels of celecoxib in the body.
  • Methotrexate: these two drugs do not affect the functioning of each other.
  • NSAIDs: concomitant use of Celecoxib with other members of the same group increases the risks of adverse events to a greater extent.
  • Anti-hypertensive: do not use ACEinh, ARBS, and diuretics with celecoxib due to the risk of antagonism of these drugs and elevation in the blood pressure.
  • Aspirin: the concurrent use of these two agents should be avoided and if required only lowest doses of aspirin should be used.
  • Lithium: should be avoided otherwise monitored proficiently because of the danger of an increase in the lithium concentrations.
  • Warfarin: observing is required as both the medications are known for bleeding risks.

What are the side effects of this drug?

It has following adverse effects;

Dyspepsia, diarrhea, stomachic, pain in the back muscles, dizziness, skin reactions, liver enzyme abnormalities, headache, raised blood pressure levels, cough, vomiting, jaundice, acidity, ulceration, bleeding, cardiac problems, liver toxicity, kidney injury, muscle ache, infections, bloating, rash, dermatitis, hepatitis, severe life-threatening allergic reaction, constriction of bronchioles in lungs.

 How does Celebrex depict its actions?

Celecoxib is an anti-inflammatory drug having pain relieving and body temperature lowering effects. It can realize these impacts by impeding the cyclooxygenase 2, a protein required for the development of provocative prostaglandins. It has no effects on the COX-1 enzyme.

How does it behave pharmacokinetically?

Pharmacokinetics of a drug involves the following processes through which it passes during its stay in the body;

  • Absorption: it reaches its optimal plasma concentrations after 3 hours.
  • Distribution: its binding is with albumin
  • Metabolism: takes place in CYP2C9 and inhibits COX-2
  • Removal: its half-life varies with the varying degree of liver and kidney performance in each patient. Feces and urine both play routes for the excretion of celecoxib from the body.

What type of ingredients is present in the capsules?

Along with Celecoxib, it contains povidone, lactose monohydrate, sodium lauryl sulfate, croscarmellose sodium, gelatin, lactose monohydrate, edible inks.

How is it used in various patient populations?

  • In children and elderlies: Celebrex is harmful to children below 2 years and in elderly the dosing is usually started at the lowest doses because of their deteriorating kidney functions.
  • Race: black descendants have some variations in their levels in comparison to Caucasians.
  • During pregnancy and lactation: pregnant women can only use Celebrex if prescribed by their doctors as it can cause abnormal organ development in the fetus. Nursing mothers should avoid this drug as low levels of it are eliminated in the milk.
  • Poor CYP2C9 metabolizers: patients having metabolic problems or variations are not given Celebrex until recommended by the specialist.

What should you tell your doctor?

Always tell your doctor about all your health problems, your medications, allergies, past significant family history before taking Celecoxib.

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