Movantik ( Naloxegol) in September 2014

F_22583 (1)

Brand name: Movantik

GenericNaloxegol, a PEGylated derivative of naloxone and a substrate for P glycoprotein transporter. 

Approval status: approved on 16thSeptember 2014

Manufacturer: AstraZeneca.

Indication: opioid induced constipation in adults with chronic non cancer pain.

Mechanism of action: it is a peripherally acting mu- opioid receptor antagonist        ( PAMORA). It shows its action in tissues like GIT, thereby decreasing the constipating effects produced by opioids. 

Dosage: it is supplied in a form of a tablet for oral administration. The recommended dosage is 25mg once daily in the morning. It is to be taken on an empty stomach at 1 hour prior to the first meal of the day, or 2 hours after taking a meal. The tablet is not to be crushed or chewed, and needs to be swallowed whole.

Precaution: Avoidance of consumption of grapefruit or grapefruit juice during treatment with Movantik. 

Metabolism : by CYP3A enzyme system. 

Half life: in a pharmacological clinical study, the half life of Naloxegol at therapeutic doses ranged from 6-11 hours.

ExcretionFollowing oral administration of radio-labelled naloxegol, 68% and 16% of total administered dose were recovered in the feces and urine, respectively

Side effects : abdominal pain,  diarrhea,  nausea, flatulence,  headache,  vomiting. 

The following drug information is obtained from various medical presentations,  journals.

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3 thoughts on “Movantik ( Naloxegol) in September 2014

  1. This medication resulted in several smal abnormal a BMs the next day, almost fecal incontinence, had to rush to the bathroom because there was no stopping it! And 2 days later, tenesmus off and on with mucus discharge that is brownish, clear. And lots of flatulence. I am opting not to continue with this medication for those reasons. Just wanted to let you know.

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